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Transcript profiling in peripheral T-cell lymphoma, not otherwise specified, and diffuse large B-cell lymphoma identifies distinct tumor profile signatures.

Abstract
To glean biological differences and similarities of peripheral T-cell lymphoma-not otherwise specified [PTCL-NOS] to diffuse large B-cell lymphoma (DLBCL), a transcriptosome analysis was done on five PTCL-NOS and four DLBCL patients and validated by quantitative real-time reverse transcription-PCR on 10 selected genes. Normal peripheral blood T cells, peripheral blood B cells, and lymph node were used as controls. The resultant gene expression profile delineated distinct "tumor profile signatures" for PTCL-NOS and DLBCL. Several highly overexpressed genes in both PTCL-NOS and DLBCL involve the immune network, stroma, angiogenesis, and cell survival cascades that make important contributions to lymphomagenesis. Inflammatory chemokines and their receptors likely play a central role in these complex interrelated pathways: CCL2 and CXCR4 in PTCL-NOS and CCL5 and CCR1 in DLBCL. Highly overexpressed oncogenes unique to PTCL-NOS are SPI1, STK6, alpha-PDGFR, and SH2D1A, whereas in DLBCL they are PIM1, PIM2, LYN, BCL2A1, and RAB13. Oncogenes common to both lymphomas are MAFB, MET, NF-kappaB2, LCK, and LYN. Several tumor suppressors are also down-regulated (TPTE, MGC154, PTCH, ST5, and SUI1). This study illustrates the relevance of tumor-stroma immune trafficking and identified potential novel prognostic markers and targets for therapeutic intervention.
AuthorsDaruka Mahadevan, Catherine Spier, Kimiko Della Croce, Susan Miller, Benjamin George, Chris Riley, Stephen Warner, Thomas M Grogan, Thomas P Miller
JournalMolecular cancer therapeutics (Mol Cancer Ther) Vol. 4 Issue 12 Pg. 1867-79 (Dec 2005) ISSN: 1535-7163 [Print] United States
PMID16373702 (Publication Type: Journal Article, Research Support, N.I.H., Extramural)
Chemical References
  • DNA Primers
  • RNA, Messenger
Topics
  • Base Sequence
  • DNA Primers
  • Gene Expression Profiling
  • Humans
  • Immunohistochemistry
  • Lymphoma, B-Cell (genetics, pathology)
  • Lymphoma, Large B-Cell, Diffuse (genetics, pathology)
  • Lymphoma, Non-Hodgkin (genetics, pathology)
  • Lymphoma, T-Cell (genetics, pathology)
  • Oligonucleotide Array Sequence Analysis
  • Oncogenes
  • RNA, Messenger (genetics)
  • Reverse Transcriptase Polymerase Chain Reaction

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