Abstract | BACKGROUND: METHODS: Baseline and follow-up data were collected on 90 RTR (mean age 51 yrs, 53% male, median transplant duration 7 years). Graft function was estimated using MDRD Study Equation 7. RESULTS: At baseline, 70% RTR had hyperuricemia (UA >7.0 mg/dl (0.42 mmol/L) in men and >6.0 mg/dl (0.36 mmol/L) in women) compared to 80% after 2.2 years (P=0.06). UA was not associated with blood pressure (BP) level but was higher in RTR with a history of hypertension compared to those without (8.6+/-1.8 vs. 7.3+/-2.2 mg/dl, [0.51+/-0.11 vs. 0.43+/-0.13 mmol/L], P=0.003) and in RTR on > or =3 antihypertensive medications compared to those taking less (9.1+/-1.6 vs. 7.6+/-1.8 mg/dL, [0.54+/-0.1 vs. 0.45+/-0.11 mmol/L], P<0.001). A history of hypertension was independently predictive of UA (beta 0.06, [95% CI 0.02 to 0.10], P=0.007) in addition to sex, cyclosporine dose, prednisolone dose, estimated glomerular filtration rate (eGFRMDRD) and beta-blocker therapy. UA was independently predictive of follow-up eGFRMDRD (beta -22.2 [95% CI -41.2 to -3.2], P=0.02) but did not predict change in eGFRMDRD over time. UA was independently associated with requirement for antihypertensive therapy (beta 0.34, [95% CI 1.05 to 1.90], P=0.02). CONCLUSIONS:
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Authors | Kirsten A Armstrong, David W Johnson, Scott B Campbell, Nicole M Isbel, Carmel M Hawley |
Journal | Transplantation
(Transplantation)
Vol. 80
Issue 11
Pg. 1565-71
(Dec 15 2005)
ISSN: 0041-1337 [Print] United States |
PMID | 16371927
(Publication Type: Journal Article)
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Chemical References |
- Antihypertensive Agents
- Biomarkers
- Diuretics
- Immunosuppressive Agents
- Uric Acid
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Topics |
- Adult
- Antihypertensive Agents
(therapeutic use)
- Biomarkers
(blood)
- Body Mass Index
- Cohort Studies
- Diuretics
(therapeutic use)
- Female
- Follow-Up Studies
- Glomerular Filtration Rate
- Humans
- Hypertension
(drug therapy, epidemiology)
- Immunosuppressive Agents
(therapeutic use)
- Kidney Transplantation
(pathology, physiology)
- Male
- Middle Aged
- Postoperative Complications
(epidemiology)
- Predictive Value of Tests
- Retrospective Studies
- Uric Acid
(blood)
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