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Ochronotic arthropathy: disappearance of alkaptonuria after liver transplantation for hepatitis B-related cirrhosis.

Abstract
The deficiency of homogentisic acid oxidase, an enzyme that is mainly found in hepatocytes, is associated with alkaptonuria and ochronosis. We report a patient with clinical and radiologic findings of ochronotic arthropathy in whom alkaptonuria disappeared and the progressive course of the disease stopped after liver transplantation for hepatitis B-related cirrhosis.
AuthorsArzu Celebi Kobak, Gonca Oder, Senol Kobak, Mehmet Argin, Vedat Inal
JournalJournal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases (J Clin Rheumatol) Vol. 11 Issue 6 Pg. 323-5 (Dec 2005) ISSN: 1076-1608 [Print] United States
PMID16371803 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Homogentisic Acid
Topics
  • Alkaptonuria (complications, diagnostic imaging, urine)
  • Female
  • Follow-Up Studies
  • Hepatitis C (complications)
  • Homogentisic Acid (urine)
  • Humans
  • Liver Cirrhosis (blood, complications, surgery)
  • Liver Transplantation
  • Lumbar Vertebrae
  • Middle Aged
  • Ochronosis (complications, diagnostic imaging, urine)
  • Radiography
  • Spondylarthritis (diagnostic imaging, etiology, urine)

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