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Immunomodulation of autoimmune and inflammatory diseases with intravenous immunoglobulin.

Abstract
Intravenous immunoglobulin (IVIg) has been used in the treatment of primary and secondary antibody deficiencies for over two decades. Since the early 1980s, the therapeutic efficacy of IVIg has been established in idiopathic thrombocytopenic purpura, Guillain-Barré syndrome, chronic inflammatory demyelinating polyneuropathy, myasthenia gravis, dermatomyositis and Kawasaki syndrome, and the prevention of graft versus host disease in recipients of allogeneic bone marrow transplants. Its use has also been reported in a large number of other autoimmune and systemic inflammatory conditions. In this review, we discuss the mechanisms by which IVIg exerts immunomodulatory effects in immune pathologies.
AuthorsA Ephrem, N Misra, G Hassan, S Dasgupta, S Delignat, J-P Duong Van Huyen, S Chamat, F Prost, S Lacroix-Desmazes, S V Kavery, M D Kazatchkine
JournalClinical and experimental medicine (Clin Exp Med) Vol. 5 Issue 4 Pg. 135-40 (Dec 2005) ISSN: 1591-8890 [Print] Italy
PMID16362793 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
Chemical References
  • Autoantibodies
  • Cytokines
  • Immunoglobulins, Intravenous
  • Complement System Proteins
Topics
  • Antigen-Presenting Cells (immunology)
  • Autoantibodies (immunology)
  • Autoimmune Diseases (drug therapy)
  • B-Lymphocytes (immunology)
  • Complement System Proteins (physiology)
  • Cytokines (biosynthesis)
  • Dendritic Cells (immunology)
  • Humans
  • Immunoglobulins, Intravenous (therapeutic use)
  • Inflammation (drug therapy, immunology)
  • Myelin Sheath
  • Neutralization Tests
  • T-Lymphocytes (immunology)

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