[Effect of Jingjielianqiao decoction on healing of skin ulcer in rats].

Abstract

OBJECTIVE:

To study the pharmacodynamics of Jingjielianqiao decoction in promoting the healing of skin ulcer in mice.

METHODS:

Mouse models of skin ulcer were established by inducing skin trauma and scald, respectively. The skin ulcer of the mice was treated with Jingjielianqiao decoction or recombinant human epithelial growth factor (rhEGF), and the ulcer area after treatment was compared between the two groups and with their respective self control. Inflammatory cell infiltration in the ulcer was observed under the microscope.

RESULTS:

Compared with the self-control group, the skin ulcer area of mice treated with Jingjielianqiao decoction was reduced obviously (P<0.001), and the inflammatory cell infiltration also alleviated (P<0.001). Jingjielianqiao decoction produced significantly better therapeutic effect than rhEGF.

CONCLUSION:

Jingjielianqiao decoction can obviously improve the healing of skin ulcer in mice with better effect than rhEGF.

• Authors: Xue-qing Liu, Kang Zeng, Hai-mei Lan, Bao-tian Chen
• Journal: Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA (Di Yi Jun Yi Da Xue Xue Bao) Vol. 25 Issue 12 Pg. 1558-9, 1562 (Dec 2005) ISSN: 1000-2588 [Print] China
• PMID: 16361164 (Publication Type: English Abstract, Journal Article)

Chemical References

• Drugs, Chinese Herbal

Topics

• Animals
• Drugs, Chinese Herbal (therapeutic use)
• Male
• Mice
• Phytotherapy
• Skin Ulcer (drug therapy)
• Wound Healing (drug effects)