Rosiglitazone protects human neuroblastoma SH-SY5Y cells against acetaldehyde-induced cytotoxicity.

Abstract

Acetaldehyde, an inhibitor of mitochondrial function, has been widely used as a neurotoxin because it elicits a severe Parkinson's disease-like syndrome with elevation of the intracellular reactive oxygen species level and apoptosis. Rosiglitazone, a peroxisome proliferator-activated receptor-gamma agonist, has been known to show various non-hypoglycemic effects, including anti-inflammatory, anti-atherogenic, and anti-apoptotic. In this study, we investigated the protective effects of rosiglitazone on acetaldehyde-induced apoptosis in human neuroblastoma SH-SY5Y cells and attempted to examine its mechanism. Acetaldehyde-induced apoptosis was moderately reversed by rosiglitazone treatment. Our results suggest that the protective effects of rosiglitazone on acetaldehyde-induced apoptosis may be ascribed to ability to induce the expression of anti-oxidant enzymes and to regulate Bcl-2 and Bax expression. These data indicate that rosiglitazone may provide a useful therapeutic strategy for the prevention of progressive neurodegenerative disease such as Parkinson's disease.

• Authors: Tae Woo Jung, Ji Young Lee, Wan Sub Shim, Eun Seok Kang, Soo Kyung Kim, Chul Woo Ahn, Hyun Chul Lee, Bong Soo Cha
• Journal: Biochemical and biophysical research communications (Biochem Biophys Res Commun) Vol. 340 Issue 1 Pg. 221-7 (Feb 03 2006) ISSN: 0006-291X [Print] United States
• PMID: 16360119 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Drug Combinations
• Neuroprotective Agents
• Thiazolidinediones
• Rosiglitazone
• Acetaldehyde

Topics

• Acetaldehyde (toxicity)
• Apoptosis (drug effects)
• Cell Line, Tumor
• Cell Survival (drug effects)
• Dose-Response Relationship, Drug
• Drug Combinations
• Humans
• Neuroblastoma (pathology, physiopathology)
• Neuroprotective Agents (administration & dosage)
• Rosiglitazone
• Thiazolidinediones (administration & dosage)