Abstract | BACKGROUND: METHODS: RESULTS: Of the 74 neonates evaluated, 65 had no signs of gastric obstruction and were considered normal; 5 had clinical and radiologic or pathological evidence of gastric obstruction consistent with the presence of antral mucosal hyperplasia. The remaining four neonates had clinical signs of gastric obstruction, but no radiologic or pathological examinations were performed. The 5 neonates with antral hyperplasia had received prostaglandin E1 for longer periods (mean [+/- SD] duration, 569 +/- 341 hours) than the 65 normal neonates (54 +/- 58 hours, P less than 0.001) or the 4 neonates with clinical signs of gastric obstruction (119 +/- 60 hours, P less than 0.05). The cumulative dose of prostaglandin E1 was higher in the neonates with antral hyperplasia (2982 +/- 1392 micrograms per kilogram of body weight) than in the normal neonates (279 +/- 270 micrograms per kilogram, P less than 0.001) or the neonates with signs of gastric obstruction (528 +/- 306 micrograms per kilogram, P less than 0.01). In two neonates with antral hyperplasia, the cessation of therapy lessened the gastric-outlet obstruction. CONCLUSIONS:
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Authors | N Peled, O Dagan, P Babyn, M M Silver, G Barker, J Hellmann, D Scolnik, G Koren |
Journal | The New England journal of medicine
(N Engl J Med)
Vol. 327
Issue 8
Pg. 505-10
(Aug 20 1992)
ISSN: 0028-4793 [Print] United States |
PMID | 1635565
(Publication Type: Case Reports, Journal Article)
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Chemical References |
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Topics |
- Alprostadil
(administration & dosage, adverse effects)
- Ductus Arteriosus
(drug effects)
- Echocardiography
- Female
- Gastric Mucosa
(drug effects, pathology)
- Heart Defects, Congenital
(drug therapy)
- Humans
- Hyperplasia
- Hypertension, Pulmonary
(drug therapy)
- Infant, Newborn
- Infusions, Parenteral
- Pyloric Antrum
(pathology)
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