[Investigation of the anti-motion sickness effect of 3-hydroxypyridine derivatives].
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| Abstract |
Experiments with rats showed that three out of 12 3-hydroxypyridine derivatives (ethyl-methyl hyd- roxypyrine succinate, SK-132 and IBCP-2 - had an anti-motion sickness effect stronger than of scopolamine, the reference vestiboloprotector. The anti-motion sickness effect of ethyl-methyl hydroxypyrine was also demonstrated in experiments with cats. Apparent anti-motion sickness effect of ethyl-methyl hydroxypyrine (mexydol) was found in 69% of healthy male volunteers which is comparable with the effect of scopolamine (62%). In experiments with immobilized cats (myorelaxation drugs) the microelectrode technique and microontoiphoresis of physiologically active substances revealed that ethylmethyl hydroxypyrine influences the majority of neurons in the medial vestibular nucleus (61%). Suppression of cell spontaneous activities in more than one half of cases can be stopped completely or attenuated significantly by bicucculine, a specific GABA(A)-receptor antagonist. In 42% of neurons ethyl-methyl hydroxypyrine subdues the response to vestibular stimulation which is likely to underlie the anti-motion sickness effect.
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| Authors | V V Iasnetsov, V A Pravdivtsev, A V Shashkov, L D Smirnov, V V Iasnetsov, S B Kozlov, Iu V Ivanov |
| Journal | Aviakosmicheskaia i ekologicheskaia meditsina = Aerospace and environmental medicine (Aviakosm Ekolog Med) 2005 Jul-Aug Vol. 39 Issue 4 Pg. 45-50 ISSN: 0233-528X [Print] Russia (Federation) |
| PMID | 16353627 (Publication Type: Comparative Study, Journal Article) |
| Chemical References |
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