[CPT-11-induced diarrhea treated with indisetron hydrochloride--a case report].

Abstract

We report a case in which 5-HT3 receptor antagonist, indisetron hydrochloride,was effective against CPT-11-induced diarrhea. When the patient, a 63-year-old male, developed lymph node metastases after resection for primary gastric cancer, 24-hour continuous administration of CPT-11 (125 mg/m2) was initiated. The following day he had diarrhea, possibly associated with the CPT-11. Hange-shashinto was administered but did not improve the condition. Thereafter, the diarrhea followed a protracted course (grade 1 to 2). His diarrhea improved when indisetron hydrochloride was administered with the fifth course of chemotherapy in place of the usual antiemetic drug. In this patient, indisetron hydrochloride, in addition to its role as an antiemetic, was considered to be effective against CPT-11-induced diarrhea.

• Authors: Mariko Kanbe, Motonobu Osada
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 32 Issue 13 Pg. 2145-7 (Dec 2005) ISSN: 0385-0684 [Print] Japan
• PMID: 16352947 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antineoplastic Agents, Phytogenic
• Bridged-Ring Compounds
• Pyrazoles
• indisetron hydrochloride
• Irinotecan
• Camptothecin

Topics

• Antineoplastic Agents, Phytogenic (adverse effects)
• Bridged-Ring Compounds (therapeutic use)
• Camptothecin (adverse effects, analogs & derivatives)
• Diarrhea (chemically induced, drug therapy)
• Drug Administration Schedule
• Humans
• Irinotecan
• Lymph Nodes (pathology)
• Lymphatic Metastasis
• Male
• Middle Aged
• Pyrazoles (therapeutic use)
• Quality of Life
• Stomach Neoplasms (drug therapy, pathology)