Abstract | BACKGROUND: METHODS: Wistar rats were subjected to transient ischemia via 10 min occlusion of the LAD coronary artery followed by 10 min of reperfusion. Animals received an IV bolus of Ringer's solution as a control (n=10) or Ringer's ethyl pyruvate (n=10) immediately before the initiation of ischemia and reperfusion. Myocardial ATP and lipid peroxidation levels were quantified for an estimation of energetics and oxidative stress, respectively. In vivo cardiac function was assessed throughout the ischemia and reperfusion periods. RESULTS:
Ethyl pyruvate significantly increased myocardial ATP levels compared to controls (2650+/-759 nmol/g versus 892+/-276 nmol/g, p=0.04). Myocardial oxidative stress was significantly reduced in animals treated with ethyl pyruvate compared to controls (70.4+/-2.6 nmol/g versus 81.8+/-2.4 nmol/g, p=0.04). dP/dt max and cardiac output were significantly greater in the ethyl pyruvate group compared to controls during ischemia and reperfusion. CONCLUSIONS:
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Authors | Matthew D Taylor, Todd J Grand, Jeffrey E Cohen, Vivien Hsu, George P Liao, Suzanne Zentko, Mark F Berry, Timothy J Gardner, Y Joseph Woo |
Journal | Heart, lung & circulation
(Heart Lung Circ)
Vol. 14
Issue 1
Pg. 25-31
(Mar 2005)
ISSN: 1443-9506 [Print] Australia |
PMID | 16352248
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Chemical References |
- Pyruvates
- ethyl pyruvate
- Adenosine Triphosphate
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Topics |
- Adenosine Triphosphate
(metabolism)
- Animals
- Cardiac Output
(drug effects)
- Coronary Artery Bypass, Off-Pump
- Disease Models, Animal
- Lipid Peroxidation
- Myocardial Reperfusion Injury
(prevention & control)
- Myocardium
(metabolism)
- Oxidative Stress
(drug effects, physiology)
- Pyruvates
(pharmacology, therapeutic use)
- Rats
- Rats, Wistar
- Ventricular Pressure
(drug effects)
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