Development of HTLV-I-associated myelopathy after blood transfusion in a patient with aplastic anemia and a recipient of a renal transplant.

Abstract

We report the development of rapid progressive HTLV-I-associated myelopathy (HAM) after blood transfusion in two immunosuppressed patients, one of whom had aplastic anemia and the other was the recipient of a renal transplant receiving immunosuppressive chemotherapy. Spastic paraparesis developed 11 or 16 months after transfusion and rapidly progressed to a wheelchair-bound state. The present 2 cases suggest that the coexistent immunosuppression may play an important role in the rapid development of HAM in transfusion-acquired cases.

• Authors: Y Kuroda, H Takashima, M Yukitake, T Sakemi
• Journal: Journal of the neurological sciences (J Neurol Sci) Vol. 109 Issue 2 Pg. 196-9 (Jun 1992) ISSN: 0022-510X [Print] Netherlands
• PMID: 1634902 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)

Topics

• Adult
• Anemia, Aplastic (complications)
• Blood Transfusion
• Blotting, Western
• Brain (pathology)
• Female
• Humans
• Immunosuppression Therapy
• Kidney Transplantation (physiology)
• Magnetic Resonance Imaging
• Male
• Middle Aged
• Paraparesis, Tropical Spastic (pathology)
• Paraplegia (etiology)