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Total synthesis and biological assessment of benzimidazole-based analogues of epothilone A: ambivalent effects on cancer cell growth inhibition.

AuthorsFréderic Cachoux, Thomas Isarno, Markus Wartmann, Karl-Heinz Altmann
JournalChembiochem : a European journal of chemical biology (Chembiochem) Vol. 7 Issue 1 Pg. 54-7 (Jan 2006) ISSN: 1439-4227 [Print] Germany
PMID16345113 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Benzimidazoles
  • Epothilones
  • epothilone A
  • benzimidazole
Topics
  • Benzimidazoles (chemistry)
  • Cell Line, Tumor
  • Cell Proliferation (drug effects)
  • Drug Screening Assays, Antitumor
  • Epothilones (chemical synthesis, chemistry, pharmacology)
  • Humans
  • Molecular Conformation
  • Stereoisomerism
  • Structure-Activity Relationship

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