Abstract | OBJECTIVE: DESIGN: Patients who had received various treatments in an ongoing randomized trial were studied prospectively. SETTING: A department of clinical immunology investigating women with recurrent spontaneous abortions from all over Denmark. PATIENTS: Eighty-nine patients with unexplained recurrent spontaneous abortions whose pregnancies had been completed during the course of the trial. INTERVENTIONS: After randomization, 44 patients were actively immunized with husband's or third party leukocytes, and 27 patients received placebo. Eighteen patients received anticoagulation therapy in pregnancy. MAIN OUTCOME MEASURES: RESULTS: Neither IgM nor IgG anticardiolipin antibodies changed significantly after active immunization (P greater than 0.2). The interim results of the immunization trial showed a success rate of 68% in the treated group versus 56% in the placebo group (not significantly different). Relative risk of miscarriage in anticardiolipin antibody-positive patients compared with anticardiolipin antibody-negative patients was 1.3 (95% confidence interval 0.7 to 2.2; P = 0.4) in the combined study groups. CONCLUSIONS: Patients eligible for active immunization did not exhibit significant changes in anticardiolipin antibody levels subsequent to the treatment. The treatment did not seem to provide any overall benefit with respect to pregnancy outcome. Prospectively, the risk of miscarriage in patients positive for anticardiolipin antibodies was not significantly increased.
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Authors | O B Christiansen, B S Christiansen, M Husth, O Mathiesen, J G Lauritsen, N Grunnet |
Journal | Fertility and sterility
(Fertil Steril)
Vol. 58
Issue 2
Pg. 328-34
(Aug 1992)
ISSN: 0015-0282 [Print] United States |
PMID | 1633897
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Antibodies
- Antigens
- Cardiolipins
- Immunoglobulin G
- Immunoglobulin M
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Topics |
- Abortion, Habitual
(immunology, prevention & control)
- Antibodies
(blood)
- Antigens
(immunology)
- Cardiolipins
(immunology)
- Enzyme-Linked Immunosorbent Assay
- Female
- Humans
- Immunization
- Immunoglobulin G
(blood)
- Immunoglobulin M
(blood)
- Leukocytes
(immunology)
- Pregnancy
- Pregnancy Outcome
- Prospective Studies
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