Abstract | BACKGROUND: METHODS: Eight-hour intragastric pH recordings were performed before and after an 8-day course of lansoprazole (30 mg once daily) in 10 H. pylori-positive male patients with reflux esophagitis and were repeated after the H. pylori eradication. Intragastric acidity was measured by using an antimony electrode placed 10 cm below the cardia. RESULTS: Baseline median preprandial, post-prandial, total intragastric pH and the percentage of time with pH < 3 were not different before and after H. pylori eradication without lansoprazole treatment. During lansoprazole treatment, median post-prandial intragastric pH was lower (4 vs 2.7; P < 0.05) and the percentage of time with pH < 3 was longer (3.4%vs 41.8%; P < 0.05) after H. pylori eradication. Median total intragastric pH tended to be lower after eradication but no difference was found in preprandial median pH. CONCLUSIONS: In patients with reflux esophagitis treated with lansoprazole, intragastric pH increased significantly when H. pylori was present, especially in the post-prandial period, whereas baseline pH remained unchanged after H. pylori eradication.
|
Authors | Adnan Giral, Cigdem A Celikel, Osman Ozdogan, Nurdan Tözün, Nefise B Ulusoy, Cem Kalayci |
Journal | Journal of gastroenterology and hepatology
(J Gastroenterol Hepatol)
Vol. 20
Issue 12
Pg. 1886-91
(Dec 2005)
ISSN: 0815-9319 [Print] Australia |
PMID | 16336449
(Publication Type: Journal Article)
|
Copyright | Copyright 2005 Blackwell Publishing Asia Pty Ltd. |
Chemical References |
- 2-Pyridinylmethylsulfinylbenzimidazoles
- Anti-Ulcer Agents
- Proton Pump Inhibitors
- Lansoprazole
- Omeprazole
|
Topics |
- 2-Pyridinylmethylsulfinylbenzimidazoles
- Adult
- Anti-Ulcer Agents
(therapeutic use)
- Gastric Acidity Determination
- Gastroesophageal Reflux
(drug therapy, microbiology)
- Gastroscopy
- Helicobacter Infections
(drug therapy)
- Helicobacter pylori
- Humans
- Hydrogen-Ion Concentration
- Lansoprazole
- Male
- Omeprazole
(analogs & derivatives, therapeutic use)
- Proton Pump Inhibitors
- Statistics, Nonparametric
- Treatment Outcome
|