[The experimental researches on the use of triamcinolone acetonide for the prevention of implant capsular contracture].
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| Abstract | OBJECTIVE: To explore the use of triamcinolone acetonide for the prevention of implant capsular contracture. METHODS: 20 rabbits were randomly undivided into 2 groups of 10 animals each. Every 10 ml silicone implant was implanted beneath the panniculus carnosus muscle of one rabbit. At the same time, a modified expander catheter was mounted on the implant. This catheter has many lateral holes and the end was blind. Triamcinolone acetonide (10 mg/3 ml) was infused through the expander pot and catheter as the experimental groups. On the other hand, 3 ml saline was used as the control group at 1, 2, and 3 months. At 6 months, measures related to contracture and capsular histology examinations were performed on anesthetized animals. RESULTS: Baker scores, capsular incision width and capsular thickness of the saline groups were evidently higher than that of triamcinolone acetonide groups (P < 0.01). Implant compression of the saline groups was evidently lower than that of triamcinolone acetonide group. Histology revealed a thinner capsules and less fibrous tissue deposition around the triamcinolone acetonide group, as compared with saline group. CONCLUSIONS: It is effective to deliver triamcinolone acetonide to reduction of capsular contracture through the catheter and its pot.
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| Authors | Wei-Qi Yang, Pei-Ying Yang, Jin-Cai Fang, Jie Luan, Xu-Hui Zhang, Zhi-Xiang Zhu |
| Journal | Zhonghua zheng xing wai ke za zhi = Zhonghua zhengxing waike zazhi = Chinese journal of plastic surgery (Zhonghua Zheng Xing Wai Ke Za Zhi) Vol. 21 Issue 5 Pg. 368-71 (Sep 2005) ISSN: 1009-4598 [Print] China |
| PMID | 16335385 (Publication Type: English Abstract, Journal Article) |
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