[The role of EPR-1 in proliferation and apoptosis in nasopharyngeal carcinoma].

Abstract

OBJECTIVE:

To investigate the relationship between the expression of effector cell protease receptor-1 (EPR-1) of coagulation serine protease factor Xa, proliferative index (Pi) ki-67 and apoptotic index (AI) in nasopharyngeal carcinoma.

METHOD:

Using immunohistochemical S-P staining and terminal deoxynucleotidyl transferase mediate dUTP nick and labeling (TUNEL) technique, the expression of EPR-1, ki-67 and AI was detected in the paraffin-embedded specimens including 42 nasopharyngeal carcinoma tissues, 42 normal nasopharyngeal tissues adjacent to the tumors tissues and 30 chronic nasopharyngitis tissues.

RESULT:

The positive rate of EPR-1 expression in the NPC tissues, normal nasopharyngeal tissues adjacent to the tumors and chronic nasopharyngeal tissues was 76.1%, 90.5%,100.0%, respectively. EPR-1 was positively correlated with AI and negatively with ki-67.

CONCLUSION:

EPR-1 play a role in increase the apoptosis and decrease the proliferation of cell. These suggest that EPR-1 may be a potential therapy for NPC.

• Authors: Ning He, Weijia Kong
• Journal: Lin chuang er bi yan hou ke za zhi = Journal of clinical otorhinolaryngology (Lin Chuang Er Bi Yan Hou Ke Za Zhi) Vol. 19 Issue 17 Pg. 782-4 (Sep 2005) China
• PMID: 16334252 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• BIRC5 protein, human
• Inhibitor of Apoptosis Proteins
• Receptors, Cell Surface
• Survivin

Topics

• Adolescent
• Adult
• Apoptosis
• Carcinoma, Squamous Cell (metabolism, pathology)
• Case-Control Studies
• Cell Proliferation
• Female
• Humans
• Inhibitor of Apoptosis Proteins
• Male
• Middle Aged
• Nasopharyngeal Neoplasms (metabolism, pathology)
• Receptors, Cell Surface (metabolism)
• Survivin
• Young Adult