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Effect of Mirazid (Commiphora molmol) on experimental heterophyidiasis.

Abstract
Mirazid (MZ), an oleo-resin extract derived from Myrrh was reported in several experimental and clinical trails to be safe and effective against other trematodes like schistosomiasis and fascioliasis. This experimental work aimed at investigating the possible efficacy of MZ against heterophyids (Pygidiopsis genata), using praziquantel as a therapeutic control. Results showed that MZ in emulsion form is a promising drug for the treatment of heterophyidiasis, as proved by significant reduction of worm count, overt surface tegumental changes like deformity and erosion of tegumental spines observed by scanning electron microscope (SEM). The effective dose regimen was 500 mg/kg/d for 3 successive days, produced 100% reduction in worm load. The proved efficacy of the drug, together with reported low toxicity, relative to praziquantel, favours its use as a natural new alternative therapy for the treatment of human heterophyidiasis.
AuthorsFouad M Fathy, Osama Salama, Ahmad M Massoud
JournalJournal of the Egyptian Society of Parasitology (J Egypt Soc Parasitol) Vol. 35 Issue 3 Pg. 1037-50 (Dec 2005) ISSN: 1110-0583 [Print] Egypt
PMID16333909 (Publication Type: Journal Article)
Chemical References
  • Emulsions
  • Plant Extracts
Topics
  • Animals
  • Commiphora (chemistry)
  • Dose-Response Relationship, Drug
  • Emulsions
  • Heterophyidae (drug effects, ultrastructure)
  • Humans
  • Microscopy, Electron, Scanning
  • Phytotherapy
  • Plant Extracts (adverse effects, pharmacology)
  • Trematode Infections (drug therapy)

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