HOMEPRODUCTSSERVICESCOMPANYCONTACTFAQResearchDictionaryPharmaMobileSign Up FREE or Login

Prevention of mouse lung tumors by targretin.

Abstract
Targretin has indicated chemotherapeutic activity against nonsmall-cell lung cancer and chemoprevention in rat mammary gland. Therefore, targretin was evaluated for the prevention of 4-(methylnitrosoamino)-1-(3-pyridyl)-1-butanol (NNK) and vinyl carbamate-induced lung tumors in female strain A mice. Three experiments were performed: (i) a dose-response study with vinyl carbamate-induced tumors; (ii) a limited treatment study also with vinyl carbamate and (iii) prevention of NNK-induced tumors. In the dose-response study, 0, 10, 30, 100 and 300 mg/kg targretin were administered after vinyl carbamate. Dose levels of 30 mg/kg and greater significantly decreased tumor multiplicity by >19%. However, the efficacy of 30 and 300 mg/kg was not significantly different demonstrating a shallow dose-response relationship. In the limited treatment study, 200 mg/kg targretin was administered to the mice from 4-13, 4-19, 4-25 and 23-25 weeks after vinyl carbamate. Administering targretin from weeks 4-19 and 4-25 decreased the multiplicity of tumors from 35.3 +/- 1.43 to 29.1 +/- 1.51 and 25.0 +/- 0.93, respectively, and along with administering it from weeks 23-25 decreased tumor size. In the third study, when targretin (100 and 300 mg/kg) was administered for 3 weeks after NNK followed by a 20 weeks holding period, tumor multiplicity was reduced from 10.6 +/- 1.13 to 6.38 +/- 0.75 and 4.60 +/- 0.70, respectively. Hence, targretin demonstrated both preventive and therapeutic activity with respect to mouse lung tumors supporting its further development as a preventive and therapeutic agent for lung cancer.
AuthorsMichael A Pereira, Paula M Kramer, Ronald Nines, Yue Liu, Fadel S Alyaqoub, William T Gunning, Vernon E Steele, Ronald A Lubet
JournalInternational journal of cancer. Journal international du cancer (Int J Cancer) Vol. 118 Issue 9 Pg. 2359-62 (May 1 2006) ISSN: 0020-7136 [Print] United States
PMID16331605 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
Copyright2005 Wiley-Liss, Inc.
Chemical References
  • Anticarcinogenic Agents
  • Nitrosamines
  • Tetrahydronaphthalenes
  • Urethane
  • 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone
  • vinyl carbamate
  • bexarotene
Topics
  • Animals
  • Anticarcinogenic Agents (pharmacology)
  • Chemoprevention
  • Dose-Response Relationship, Drug
  • Female
  • Lung Neoplasms (prevention & control)
  • Mice
  • Neoplasms, Experimental (prevention & control)
  • Nitrosamines (administration & dosage)
  • Tetrahydronaphthalenes (pharmacology)
  • Urethane (administration & dosage, analogs & derivatives)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!


Choose Username:
Email:
Password:
Verify Password: