The combination of cisplatin and vinorelbine with concurrent thoracic radiation therapy for locally advanced stage IIIA or IIIB non-small-cell lung cancer.

Abstract

AIMS:

The aims of this study were to assess the efficacy and toxicity of concurrent chemoradiotherapy with divided schedule of cisplatin and vinorelbine in patients with locally advanced non-small-cell lung cancer (NSCLC).

METHODS:

Patients with previously untreated, unresectable, and stage IIIA or IIIB NSCLC were eligible if they had a performance status of 0 or 1, were 75 years or younger, and had adequate organ function. Twenty-six patients (24 men and 2 women; median age, 66 years; age range, 42-75 years) were enrolled. Both cisplatin (40 mg/m(2)) and vinorelbine (20 mg/m(2)) were given on days 1 and 8 every 3 weeks. Beginning on day 2 of chemotherapy, thoracic radiotherapy was given for approximately 6 weeks (2 Gy per fraction; total dose, 60 Gy).

RESULTS:

Five of the 26 patients achieved a complete response, and 16 achieved a partial response for an overall response rate of 80.8% (95% confidence interval, 60.6-93.4%). The median survival time was 23 months (range, 4-43 months). Overall survival rates at 1 and 2 years were 80 and 56%, respectively. Hematologic toxicities included grade 3-4 neutropenia in 84.6% of patients, grade 3-4 thrombocytopenia in 3.8%, and grade 3-4 anemia in 61.5%. Two patients (7.7%) had grade 3 radiation esophagitis that resolved completely without dilation. Grade 3-4 radiation pneumonitis occurred in two patients (7.7%) and was treated with corticosteroids. Both patients had a good partial resolution of symptoms and radiographic abnormalities. There were no treatment-related deaths. The actual delivered dose intensities for both cisplatin and vinorelbine were 79.5%. Radiotherapy was completed in 96% of patients.

CONCLUSION:

Concurrent chemoradiotherapy with cisplatin and vinorelbine administered on a divided schedule is effective and well tolerated in patients with locally advanced NSCLC.

• Authors: Takashi Hirose, Yoshihide Mizutani, Tohru Ohmori, Hiroo Ishida, Takamichi Hosaka, Kohichi Ando, Takao Shirai, Kentaro Okuda, Tsukasa Ohnishi, Naoya Horichi, Hayato Kubota, Mitsuru Adachi
• Journal: Cancer chemotherapy and pharmacology (Cancer Chemother Pharmacol) Vol. 58 Issue 3 Pg. 361-7 (Sep 2006) ISSN: 0344-5704 [Print] Germany
• PMID: 16331494 (Publication Type: Clinical Trial, Phase II, Journal Article)

Chemical References

• Vinblastine
• Cisplatin
• Vinorelbine

Topics

• Adult
• Aged
• Antineoplastic Combined Chemotherapy Protocols (administration & dosage, adverse effects, therapeutic use)
• Carcinoma, Non-Small-Cell Lung (drug therapy, pathology, radiotherapy)
• Cisplatin (administration & dosage, adverse effects, therapeutic use)
• Combined Modality Therapy
• Disease-Free Survival
• Dose-Response Relationship, Drug
• Drug Administration Schedule
• Female
• Humans
• Lung Neoplasms (drug therapy, pathology, radiotherapy)
• Male
• Middle Aged
• Neoplasm Staging
• Radiation Dosage
• Thorax
• Treatment Outcome
• Vinblastine (administration & dosage, adverse effects, analogs & derivatives, therapeutic use)
• Vinorelbine