Prognostic relevance of large-platelet counts in patients with immune thrombocytopenic purpura.

In this preliminary study, the value of different platelet parameters, measured by the ADVIA120 Analyzer, in predicting the immediate response to intravenous immunoglobulin or intravenous anti-RhoD was assessed in 31 patients with immune thrombocytopenic purpura. The number of large platelets pre-treatment was the only independent predictor of the 24 hour-platelet increase.
AuthorsMarc Michel, Felix Kreidel, E Sabrinah Chapman, David Zelmanovic, James B Bussel
JournalHaematologica (Haematologica) Vol. 90 Issue 12 Pg. 1715-6 (Dec 2005) ISSN: 1592-8721 [Electronic] Italy
PMID16330456 (Publication Type: Comparative Study, Evaluation Studies, Letter)
Chemical References
  • Immunoglobulins, Intravenous
  • Isoantibodies
  • RHO(D) antibody
  • Rho(D) Immune Globulin
  • Adolescent
  • Adult
  • Aged
  • Blood Platelets (ultrastructure)
  • Cell Size
  • Child
  • Combined Modality Therapy
  • Disease Progression
  • Female
  • Humans
  • Immunoglobulins, Intravenous (therapeutic use)
  • Isoantibodies (therapeutic use)
  • Male
  • Middle Aged
  • Pilot Projects
  • Platelet Count
  • Prognosis
  • Purpura, Thrombocytopenic, Idiopathic (blood, mortality, surgery, therapy)
  • Rho(D) Immune Globulin
  • Splenectomy

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