The prognostic value of cN-II and cN-III enzymes in adult acute myeloid leukemia.

Abstract

We analyzed the expression of deoxycytidine kinase (dCK), UMP/CMP-kinase (UMP/CMP-K), nucleotide diphosphokinase (NDPK-B) and 5'-nucleotidases cN-II, cN-III, cdN and mdN by quantitative polymerase chain reaction at diagnosis in leukemic blasts from 96 patients with acute myeloid leukemia (AML) treated with ara-C. Our results show that high mRNA levels of cN-II and low mRNA levels of cN-III are correlated with a worse clinical outcome and suggest that these enzymes may have a role in sensitivity to ara-C in AML patients.

• Authors: Carlos María Galmarini, Emeline Cros, Xavier Thomas, Lars Jordheim, Charles Dumontet
• Journal: Haematologica (Haematologica) Vol. 90 Issue 12 Pg. 1699-701 (Dec 2005) ISSN: 1592-8721 [Electronic] Italy
• PMID: 16330448 (Publication Type: Letter)

Chemical References

• Antimetabolites, Antineoplastic
• Glycoproteins
• Neoplasm Proteins
• Pyrimidine Nucleotides
• RNA, Messenger
• RNA, Neoplasm
• Cytarabine
• 5'-Nucleotidase
• NT5C2 protein, human
• NT5C3A protein, human

Topics

• 5'-Nucleotidase (biosynthesis, genetics)
• Acute Disease
• Adult
• Aged
• Antimetabolites, Antineoplastic (administration & dosage, pharmacokinetics)
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Bone Marrow Cells (enzymology)
• Cytarabine (administration & dosage, pharmacokinetics)
• Drug Resistance, Neoplasm (genetics)
• Female
• Glycoproteins (biosynthesis, genetics)
• Humans
• Leukemia, Myeloid (drug therapy, enzymology, genetics, mortality)
• Male
• Middle Aged
• Neoplasm Proteins (biosynthesis, genetics)
• Neoplastic Stem Cells (enzymology)
• Prognosis
• Proportional Hazards Models
• Pyrimidine Nucleotides (metabolism)
• RNA, Messenger (analysis, blood)
• RNA, Neoplasm (analysis, blood)
• Reverse Transcriptase Polymerase Chain Reaction
• Survival Analysis
• Treatment Outcome