| Abstract | HIV-1 infection is a major pandemic situation. With the advent of highly active antiretroviral therapy (HAART), morbidity and mortality associated with HIV-1 infection have been dramatically reduced. However, HAART does not enable eradication of the virus. The efficacy of these new regimens is limited by problems over long-term use such as toxicity and resistance. Therapeutic vaccination is an alternative approach to HIV-1 infection. The main aim is to boost and reinforce virus-specific host immune responses. Several immunogens and schedules of immunization have been tested. In this review, various strategies designed for therapeutic vaccines for HIV-1 infection are presented. |
| Authors | M Lazrek, P E Lobert, A Goffard, C Schanen, A Dewilde, L Bocket, D Hober
(Affiliation: Service de virologie, UPRES EA 3610, CHRU de Lille.)
|
| Journal | Annales de biologie clinique
(Ann Biol Clin (Paris))
2005 Nov-Dec
Vol. 63
Issue 6
Pg. 581-8
ISSN: 0003-3898 France |
| Vernacular Title | Différentes approches de vaccination thérapeutique dans le traitement de l'infection par le VIH-1. |
| PMID | 16330376
(Publication Type: English Abstract, Journal Article, Review)
|
| Chemical References |
|
| Topics |
- AIDS Vaccines
(therapeutic use)
- HIV Infections
(drug therapy)
- HIV-1
- Humans
|
