Abstract | BACKGROUND: OBJECTIVE: METHODS: In this single-center, multiple-dose, open-label study, healthy adult subjects received a single oral dose of memantine hydrochloride (20 mg) on day 1. After a 14-day washout period, subjects were orally administered 1.25-mg glyburide/250-mg metformin BID with food for 6 days. On day 21, subjects were coadministered memantine (20 mg) and glyburide/metformin with food. Assessments included determination of pharmacokinetic parameters for memantine and the antidiabetic agents when administered alone and in combination, pharmacodynamic measurements of blood glucose levels, and analyses of tolerability. RESULTS: The study population consisted of 24 subjects (13 women, 11 men; 79.2% white) with a mean (SD) age of 26.1 (5.6) years and a mean (SD) weight of 69.5 (11.3) kg. Twenty-one subjects completed the study: 2 discontinued due to adverse events judged unrelated to study medication, and 1 withdrew consent. No significant pharmacokinetic or pharmacodynamic interactions were observed between memantine and glyburide/metformin. Adverse events included dizziness (41.7% of patients) with memantine administration and gastrointestinal effects ( nausea, 9.1 %; vomiting, 9.1%; abdominal cramps, 13.6%) with glyburide/metformin administration. CONCLUSIONS:
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Authors | Niranjan Rao, Thomas Chou, Daniel Ventura, Wattanaporn Abramowitz |
Journal | Clinical therapeutics
(Clin Ther)
Vol. 27
Issue 10
Pg. 1596-606
(Oct 2005)
ISSN: 0149-2918 [Print] United States |
PMID | 16330295
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Drug Combinations
- Metformin
- Glyburide
- Memantine
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Topics |
- Adult
- Alzheimer Disease
(drug therapy)
- Diabetes Mellitus, Type 2
(drug therapy)
- Drug Combinations
- Drug Interactions
- Female
- Glyburide
(administration & dosage, pharmacokinetics, pharmacology)
- Humans
- Male
- Memantine
(pharmacokinetics, pharmacology)
- Metformin
(administration & dosage, pharmacokinetics, pharmacology)
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