| Abstract | INTRODUCTION: Adult-onset Still disease can have severe manifestations, the treatment of which is not yet codified. CASE: The authors report a case of life-threatening adult-onset Still disease with hemophagocytic syndrome, which improved dramatically with cyclosporin A. Despite the presence of severe pancytopenia, adult-onset Still disease is suggested by the combination of sore throat, myalgia, rash, hepatitis, high serum ferritin, low glycosylated ferritin, and negative etiologic findings. DISCUSSION: Still disease may be present in patients with febrile pancytopenia, and cyclosporine may be a useful treatment after corticosteroid failure. |
| Authors | M Hamidou, D Boutoille, A Masseau, R Garand, F Raffi
(Affiliation: Service de médecine interne, CHU Hôtel-Dieu, Nantes (44). mohamed.hamidou at chu-nantes.fr)
|
| Journal | Presse médicale (Paris, France : 1983)
(Presse Med)
Vol. 34
Issue 21
Pg. 1634-6
(Dec 3 2005)
ISSN: 0755-4982 France |
| Vernacular Title | Maladie de Still de l'adulte avec syndrome d'activation macrophagique. Intérêt de la ciclosporine. |
| PMID | 16327702
(Publication Type: Case Reports, English Abstract, Journal Article)
|
| Chemical References |
- Antirheumatic Agents
- Cyclosporine
|
| Topics |
- Antirheumatic Agents
(therapeutic use)
- Cyclosporine
(therapeutic use)
- Female
- Fever
(etiology)
- Humans
- Lymphohistiocytosis, Hemophagocytic
(etiology)
- Middle Aged
- Pancytopenia
(etiology)
- Still's Disease, Adult-Onset
(complications, drug therapy)
- Treatment Outcome
|
