Abstract | OBJECTIVE: To investigate the expression status of topoisomerase IIIa in epithelial ovarian tumor and the relationship between the expression status of topoisomerase IIIa and pathological type and clinical stage of epithelial ovarian carcinoma. METHODS: RESULTS: The expression rate of topoisomerase IIIa was 17.9% in the benign ovarian tumors, 74.0% in the borderline cystadenoma, and 42.7% in the malignant tumors with statistical significance among them (chi(2) = 24.657, P < 0.001). There was no correlation between the expression of topoisomerase IIIa and the clinical stage or pathological grade of the tumors (P = 0.903 and P = 0.844). CONCLUSION:
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Authors | Wen-ying Zhang, Ying Pan, Li-rong Zhu, Jian-zhong Zhang, Ming Zhang, Kai Feng, Ling Zhou, Li Yu, Xiao-mei Zhang, Shu-wing Ng |
Journal | Zhonghua yi xue za zhi
(Zhonghua Yi Xue Za Zhi)
Vol. 85
Issue 42
Pg. 2988-91
(Nov 09 2005)
ISSN: 0376-2491 [Print] China |
PMID | 16324386
(Publication Type: Journal Article)
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Chemical References |
- Isoenzymes
- DNA Topoisomerases, Type I
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Topics |
- Adult
- Cystadenoma, Mucinous
(enzymology, pathology)
- Cystadenoma, Serous
(enzymology, pathology)
- DNA Topoisomerases, Type I
(biosynthesis)
- Female
- Humans
- Immunohistochemistry
- Isoenzymes
(biosynthesis)
- Middle Aged
- Neoplasm Staging
- Ovarian Neoplasms
(enzymology, pathology)
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