Antiatherosclerotic properties of oral cicaprost in hypercholesterolemic rabbits.

Abstract

The effects of the orally active prostacyclin mimetic cicaprost on morphologic and functional alterations of rabbit aorta was investigated in experimental hypercholesterolemia. Oral cicaprost resulted in a significantly reduced aortic atheromatous plaque formation and partially prevented hypercholesterolemia-induced impairment of endothelium-dependent relaxations. It is concluded that long-term substitution with PGI2 may beneficially influence the progression of atherosclerosis.

• Authors: M Braun, M Sarbia, P Kienbaum, T Hohlfeld, A Weber, K Schrör
• Journal: Agents and actions. Supplements (Agents Actions Suppl) Vol. 37 Pg. 282-8 ( 1992) ISSN: 0379-0363 [Print] Switzerland
• PMID: 1632302 (Publication Type: Journal Article)

Chemical References

• Lipids
• Epoprostenol
• cicaprost

Topics

• Administration, Oral
• Animals
• Aorta, Thoracic (pathology)
• Arteriosclerosis (pathology, physiopathology, prevention & control)
• Blood Vessels (pathology, physiopathology)
• Epoprostenol (administration & dosage, analogs & derivatives, therapeutic use)
• Hypercholesterolemia (complications)
• Lipids (blood)
• Muscle Relaxation (physiology)
• Muscle, Smooth, Vascular (physiology)
• Rabbits