Abstract | BACKGROUND: METHODS: Forty-five patients with stable NYHA class II-IV CHF (64.0+/-15.5 years), ejection fraction <40%, were included in this prospective double-blind study and randomized to receive aspirin 325 mg/day or clopidogrel 75 mg/day for 14 days. Reflected wave assessed by radial applanation tonometry and pulse wave velocity (PWV) were measured at day 0 and day 14. RESULTS:
Aspirin resulted in an increase in the augmentation index of the reflected wave (Delta=+3.5+/-5.2%, p=0.005) and the height above the shoulder of the reflected wave (Delta=+1.7+/-3.1 mm Hg, p=0.023), without statistically variation in PWV. Conversely, clopidogrel had no effect on the same parameters (p=0.512, p=0.677 and 0.801, respectively). Overall, variations in the augmentation index of reflected wave significantly differed when compared aspirin with clopidogrel (p=0.0261). CONCLUSION: This study demonstrates the existence of a negative effect of aspirin 325 mg/day when compared to clopidogrel 75 mg/day on arterial functional properties in CHF patients treated with ACEI.
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Authors | Christophe Meune, Isabelle Mahé, Alain Cohen Solal, Bernard I Lévy, Denis Duboc, Guy Simoneau, Karine Champion, Jean-Jacques Mourad, Simon Weber, Jean-François Bergmann |
Journal | International journal of cardiology
(Int J Cardiol)
Vol. 106
Issue 1
Pg. 61-6
(Jan 04 2006)
ISSN: 0167-5273 [Print] Netherlands |
PMID | 16321668
(Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Angiotensin-Converting Enzyme Inhibitors
- Platelet Aggregation Inhibitors
- Clopidogrel
- Ticlopidine
- Aspirin
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Topics |
- Aged
- Angiotensin-Converting Enzyme Inhibitors
(therapeutic use)
- Aspirin
(administration & dosage, adverse effects)
- Chi-Square Distribution
- Clopidogrel
- Double-Blind Method
- Female
- Heart Failure
(drug therapy)
- Humans
- Male
- Middle Aged
- Platelet Aggregation Inhibitors
(administration & dosage, adverse effects)
- Prospective Studies
- Ticlopidine
(administration & dosage, adverse effects, analogs & derivatives)
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