[Effects of isosorbide-5-mononitrate on clinical condition, bicycle ergometry results, endothelium-dependent vasodilation in patients with ischemic heart disease with stable effort angina].

Abstract

AIM:

Assessment of efficacy of treatment of coronary heart disease (CHD) patients suffering from stable effort angina of functional class II-III with the drug isosorbide-5-mononitrate Mono Mac 50 depo (MM 50 D).

MATERIAL AND METHODS:

Clinical indices, exercise tolerance, endothelial function (the study of brachial artery in reactive hyperemia and sublingual intake of nitroglycerin) were studied in 30 patients with stable angina FC II-III before the treatment, 1 and 3 months after the treatment.

RESULTS:

MM 50D significantly widens diameter of the brachial artery (by 11.6%), lowers nitroglycerin-dependent vasodilation (from 16% to 10.4% in a month and to 10.2% in 3 months) and blood flow speed in reactive hyperemia. An absolute increment of the brachial artery diameter in reactive hyperemia test remained unchanged. The ratio flow-dependent vasodilation/nitroglycerin-dependent vasodilation increased in the course of therapy from 0.67 to 0.91. The drug produced clinical improvement (anginal attacks rate diminished by 70 and 85%, respectively) and increased exercise tolerance (the threshold performance rose by 28%, total load time--by 30%).

CONCLUSION:

It is important to use complex assessment of hemodynamic component of endothelial function in the treatment with nitrates.

• Authors: S S Kazachkina, T V Balakhonova, V P Lupanov, O A Pogorelova, A N Rogoza, V G Naumov
• Journal: Terapevticheskii arkhiv (Ter Arkh) Vol. 77 Issue 10 Pg. 71-5 ( 2005) ISSN: 0040-3660 [Print] Russia (Federation)
• PMID: 16320691 (Publication Type: Journal Article)

Chemical References

• Vasodilator Agents
• Nitroglycerin
• Isosorbide Dinitrate
• isosorbide-5-mononitrate

Topics

• Adult
• Aged
• Angina Pectoris (classification, complications, diagnostic imaging, drug therapy, physiopathology)
• Blood Flow Velocity (drug effects)
• Brachial Artery (diagnostic imaging, drug effects, physiopathology)
• Endothelium, Vascular (diagnostic imaging, drug effects, physiopathology)
• Exercise Test
• Exercise Tolerance (drug effects)
• Follow-Up Studies
• Humans
• Isosorbide Dinitrate (analogs & derivatives, therapeutic use)
• Male
• Middle Aged
• Myocardial Ischemia (diagnostic imaging, drug therapy, physiopathology)
• Nitroglycerin (therapeutic use)
• Physical Exertion
• Time Factors
• Treatment Outcome
• Ultrasonography
• Vasodilation (drug effects, physiology)
• Vasodilator Agents (therapeutic use)