Abstract | PURPOSE OF REVIEW: RECENT FINDINGS: These observations, together with the known association of autoimmunity to proteinase 3 and neutrophil elastase in Wegener's granulomatosis, support the concept that there is a natural immunity to primary granule proteins which can be boosted to enhance immunity to leukemia. Preliminary reports indicate that PR1 peptide vaccination induces significant increases in PR1-specific cytotoxic T cells with rapid and durable remissions in some patients with advanced myeloid leukemias. SUMMARY:
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Authors | John Barrett, Katayoun Rezvani |
Journal | Current opinion in hematology
(Curr Opin Hematol)
Vol. 13
Issue 1
Pg. 15-20
(Jan 2006)
ISSN: 1065-6251 [Print] United States |
PMID | 16319682
(Publication Type: Journal Article, Review)
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Chemical References |
- Antigens, Neoplasm
- Cancer Vaccines
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Topics |
- Animals
- Antigens, Neoplasm
(immunology, therapeutic use)
- CD8-Positive T-Lymphocytes
(immunology)
- Cancer Vaccines
(therapeutic use)
- Granulomatosis with Polyangiitis
(immunology, pathology)
- Humans
- Immunotherapy, Active
(methods)
- Leukemia, Myelogenous, Chronic, BCR-ABL Positive
(immunology, therapy)
- Myelodysplastic Syndromes
(immunology, pathology, therapy)
- Myeloid Progenitor Cells
(immunology, pathology)
- Neutrophils
(immunology, pathology)
- Secretory Vesicles
(immunology, metabolism)
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