Abstract | OBJECTIVE: METHODS: RESULTS: CONCLUSION: While, to date, several evidences have indicated that the mechanisms by which 14-membered ring macrolides reduce inflammation are not simply bactericidal, these results suggest another new mechanism of efficacy of macrolides in treating chronic rhinosinusitis.
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Authors | Shoji Matsune, Dong Sun, Junichiro Ohori, Kengo Nishimoto, Tatsuya Fukuiwa, Masato Ushikai, Yuichi Kurono |
Journal | The Laryngoscope
(Laryngoscope)
Vol. 115
Issue 11
Pg. 1953-6
(Nov 2005)
ISSN: 0023-852X [Print] United States |
PMID | 16319604
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anti-Bacterial Agents
- Macrolides
- RNA, Messenger
- Vascular Endothelial Growth Factor A
- Roxithromycin
- Clarithromycin
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Topics |
- Adult
- Anti-Bacterial Agents
(therapeutic use)
- Cells, Cultured
- Clarithromycin
(therapeutic use)
- Fibroblasts
(drug effects, pathology)
- Gene Expression
(drug effects)
- Humans
- In Vitro Techniques
- Macrolides
(therapeutic use)
- Nasal Polyps
(drug therapy, metabolism, pathology)
- RNA, Messenger
(drug effects, genetics)
- Reverse Transcriptase Polymerase Chain Reaction
- Roxithromycin
(therapeutic use)
- Vascular Endothelial Growth Factor A
(antagonists & inhibitors, biosynthesis, genetics)
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