Abstract | BACKGROUND: The antiemetic efficacy of serotonin-type 3 (5-HT3) receptor antagonists has been found to be superior to older antiemetic drugs in cancer patients. Following the administration of these agents, changes in ECG parameters and increased or decreased heart rates have been demonstrated, but there is no sufficient data in children with cancer who are treated with cytotoxic agents. The objective of this study is to evaluate the ECG changes after administration of 5-HT3 receptor antagonists and chemotherapeutic agents in children with cancer. PROCEDURE: RESULTS: We found a significant shortening of the PR interval and QRS complex durations in the granisetron group at 90th min and at 24th hr, respectively. Also, granisetron infusion caused a significant prolongation of the QTca interval at 90 min. CONCLUSION: Although we observed minor ECG changes after 5-HT3 receptor antagonists and chemotherapy, neither dangerous rhythm disturbances nor serious ECG changes were seen.
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Authors | F G Pinarli, M Elli, A Dagdemir, K Baysal, S Acar |
Journal | Pediatric blood & cancer
(Pediatr Blood Cancer)
Vol. 47
Issue 5
Pg. 567-71
(Oct 15 2006)
ISSN: 1545-5009 [Print] United States |
PMID | 16317736
(Publication Type: Clinical Trial, Journal Article)
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Copyright | Copyright (c) 2005 Wiley-Liss, Inc. |
Chemical References |
- Antiemetics
- Serotonin 5-HT3 Receptor Antagonists
- Serotonin Antagonists
- Ondansetron
- Granisetron
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Topics |
- Adolescent
- Adult
- Antiemetics
(administration & dosage)
- Antineoplastic Combined Chemotherapy Protocols
(adverse effects, therapeutic use)
- Child
- Child, Preschool
- Electrocardiography
(drug effects)
- Female
- Granisetron
(administration & dosage)
- Heart Rate
(drug effects)
- Humans
- Male
- Nausea
(chemically induced, prevention & control)
- Neoplasms
(drug therapy)
- Ondansetron
(administration & dosage)
- Predictive Value of Tests
- Serotonin 5-HT3 Receptor Antagonists
- Serotonin Antagonists
(administration & dosage)
- Treatment Outcome
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