Abstract | OBJECTIVE: METHODS: It is a multicentral, randomized, double blind, double placebo and paralled comparative study with positive control. One hundred and forty IDA patients diagnosed according to the standard criteria in three hospitals were randomly divided into a test group (ferrous L- threonate plus placebo ferrous succinate) and a positive control group ( ferrous succinate plus placebo ferrous L- threonate). Some iron parameters were examined 1, 4 and 8 weeks after medication. Hemoglobin, reticulocyte and other parameters for safety observation were collected every two weeks. RESULTS: For the 2 groups, self comparison showed significant difference (P < 0.01). The total efficacy is 98.44% and 97.01% respectively with no difference. Hemoglobin rised rapidly and gradually and reached a peak in week 8, the change was statistically significant (P < 0.01). Changes of iron parameters also showed significant difference. Side-effects were similar in both groups (13.85% and 14.71%, P > 0.05). CONCLUSION: The effect of ferrous L- threonate in IDA treatment is significant and rapid. Side-effects are few and minimal.
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Authors | Xiang-xin Li, Xue-liang Chen, Mao-hong Zhang, Yan-hua Wang, Wan-ming Da, Jian-yong Li |
Journal | Zhonghua nei ke za zhi
(Zhonghua Nei Ke Za Zhi)
Vol. 44
Issue 11
Pg. 844-7
(Nov 2005)
ISSN: 0578-1426 [Print] China |
PMID | 16316567
(Publication Type: English Abstract, Journal Article, Multicenter Study, Randomized Controlled Trial)
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Chemical References |
- Ferrous Compounds
- Ferritins
- Iron
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Topics |
- Administration, Oral
- Adolescent
- Adult
- Aged
- Anemia, Iron-Deficiency
(drug therapy)
- Double-Blind Method
- Female
- Ferritins
(blood)
- Ferrous Compounds
(administration & dosage, adverse effects, therapeutic use)
- Humans
- Iron
(blood)
- Male
- Middle Aged
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