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[A randomized controlled and multicenter clinical study of ferrous L-threonate in treatment of iron deficiency anemia].

AbstractOBJECTIVE:
To study the clinical efficacy and side effects of ferrous L-threonate for treatment of iron deficiency anemia (IDA).
METHODS:
It is a multicentral, randomized, double blind, double placebo and paralled comparative study with positive control. One hundred and forty IDA patients diagnosed according to the standard criteria in three hospitals were randomly divided into a test group (ferrous L-threonate plus placebo ferrous succinate) and a positive control group (ferrous succinate plus placebo ferrous L-threonate). Some iron parameters were examined 1, 4 and 8 weeks after medication. Hemoglobin, reticulocyte and other parameters for safety observation were collected every two weeks.
RESULTS:
For the 2 groups, self comparison showed significant difference (P < 0.01). The total efficacy is 98.44% and 97.01% respectively with no difference. Hemoglobin rised rapidly and gradually and reached a peak in week 8, the change was statistically significant (P < 0.01). Changes of iron parameters also showed significant difference. Side-effects were similar in both groups (13.85% and 14.71%, P > 0.05).
CONCLUSION:
The effect of ferrous L-threonate in IDA treatment is significant and rapid. Side-effects are few and minimal.
AuthorsXiang-xin Li, Xue-liang Chen, Mao-hong Zhang, Yan-hua Wang, Wan-ming Da, Jian-yong Li
JournalZhonghua nei ke za zhi (Zhonghua Nei Ke Za Zhi) Vol. 44 Issue 11 Pg. 844-7 (Nov 2005) ISSN: 0578-1426 [Print] China
PMID16316567 (Publication Type: English Abstract, Journal Article, Multicenter Study, Randomized Controlled Trial)
Chemical References
  • Ferrous Compounds
  • Ferritins
  • Iron
Topics
  • Administration, Oral
  • Adolescent
  • Adult
  • Aged
  • Anemia, Iron-Deficiency (drug therapy)
  • Double-Blind Method
  • Female
  • Ferritins (blood)
  • Ferrous Compounds (administration & dosage, adverse effects, therapeutic use)
  • Humans
  • Iron (blood)
  • Male
  • Middle Aged

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