Abstract |
Cancer cell metabolism is characterized by limited oxidative phosphorylation in order to minimize oxidative stress. We have previously shown that the flavonoid flavone in HT-29 colon cancer cells increases the uptake of pyruvate or lactate into mitochondria, which is followed by an increase in O(2) (-.). production that finally leads to apoptosis. Similarly, a supply of palmitoylcarnitine in combination with carnitine induces apoptosis in HT-29 cells by increasing the mitochondrial respiration rate. Here we show that flavone-induced apoptosis is increased more than twofold in the presence of palmitoylcarnitine due to increased mitochondrial fatty acid transport and the subsequent metabolic generation of O(2) (-.) in mitochondria is the initiating factor for the execution of apoptosis.
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Authors | U Wenzel, A Nickel, H Daniel |
Journal | Cellular and molecular life sciences : CMLS
(Cell Mol Life Sci)
Vol. 62
Issue 24
Pg. 3100-5
(Dec 2005)
ISSN: 1420-682X [Print] Switzerland |
PMID | 16314920
(Publication Type: Journal Article)
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Chemical References |
- Flavones
- Superoxides
- Palmitoylcarnitine
- Carnitine
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Topics |
- Apoptosis
(drug effects, physiology)
- Biological Transport
(drug effects, physiology)
- Carnitine
(metabolism)
- Colonic Neoplasms
(drug therapy, metabolism)
- Flavones
(antagonists & inhibitors, pharmacology)
- HT29 Cells
- Humans
- Mitochondria
(chemistry, drug effects, metabolism)
- Oxidative Stress
(drug effects, physiology)
- Palmitoylcarnitine
(metabolism, pharmacology)
- Superoxides
(metabolism)
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