Interstitial nephritis and high titers of PR3-ANCA: an unusual manifestation of ANCA-associated disease.

Abstract

We present the case of a 75-year-old female with weight loss, anemia, systemic signs of inflammation, mild renal insufficiency, microscopic hematuria, mixed glomerular and tubular proteinuria, and high titers of PR3-ANCA. Renal biopsy demonstrated interstitial nephritis with some sclerosed but otherwise normal glomeruli. Extensive work-up showed no signs of granulomatous inflammation or other vasculitic organ involvement. We presumed this to be a rare renal manifestation of ANCA-associated disease with the presence of sclerosed glomeruli suggesting a previous history of glomerular involvement. In view of the absence of active vasculitic or granulomatous disease, treatment was limited to low-dose corticosteroids with good response.

• Authors: U Schönermarck, C A Schirren, N Mistry-Burchardi, M Weiss, P Eichhorn, W Samtleben
• Journal: Clinical nephrology (Clin Nephrol) Vol. 64 Issue 5 Pg. 383-6 (Nov 2005) ISSN: 0301-0430 [Print] Germany
• PMID: 16312267 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antibodies, Antineutrophil Cytoplasmic
• Serine Endopeptidases
• Myeloblastin

Topics

• Aged
• Antibodies, Antineutrophil Cytoplasmic (blood)
• Female
• Humans
• Myeloblastin
• Nephritis, Interstitial (blood)
• Serine Endopeptidases (blood)