| Abstract | BACKGROUND: Toxoplasmosis is a leading cause of retinochoroiditis. Conventional multidrug therapy using sulfadiazine, pyrimethamine, and folinic acid is increasingly difficult to procure and administer safely. METHODS: To evaluate the efficacy of trimethoprim-sulfamethoxazole, a fixed-combination antibiotic, patients with active toxoplasmosis were treated with trimethoprim-sulfamethoxazole (Bactrim DS) with or without adjunctive clindamycin and prednisone for 4 to 6 weeks. RESULTS: All patients in this study (n = 16) had resolution of active retinochoroiditis and had improved vision, with an average gain of 5.2 lines of vision. Two patients developed a drug allergy. CONCLUSION: Trimethoprim-sulfamethoxazole appears to be a safe and effective substitute for sulfadiazine, pyrimethamine, and folinic acid (Leucovorin) in treating ocular toxoplasmosis. |
| Authors | E M Opremcak, D K Scales, M R Sharpe
(Affiliation: Ohio State University, College of Medicine, Department of Ophthalmology, Columbus 43210.)
|
| Journal | Ophthalmology
(Ophthalmology)
Vol. 99
Issue 6
Pg. 920-5
(Jun 1992)
ISSN: 0161-6420 UNITED STATES |
| PMID | 1630782
(Publication Type: Case Reports, Journal Article)
|
| Chemical References |
- Clindamycin
- Prednisone
- Trimethoprim-Sulfamethoxazole Combination
|
| Topics |
- Adolescent
- Adult
- Aged
- Child
- Chorioretinitis
(drug therapy, parasitology)
- Clindamycin
(therapeutic use)
- Drug Tolerance
- Female
- Fundus Oculi
- Humans
- Male
- Middle Aged
- Prednisone
(therapeutic use)
- Toxoplasmosis, Ocular
(drug therapy)
- Trimethoprim-Sulfamethoxazole Combination
(therapeutic use)
- Visual Acuity
|
