Abstract | AIMS: METHODS: We searched MEDLINE, EMBASE, and the Cochrane Controlled Trials Register of the Cochrane Library (1966-2004). Keywords used were: polycythemia, partial exchange transfusion, hyperviscosity, and limited to newborn. Randomized studies in newborns with polycythemia were selected for evaluation. Outcomes examined were: long-term neurodevelopment; short-term physiological effects; improvement in clinical symptoms; reduction in haematocrit at 4-6 h; haematocrit at 24 h; and frequency of serious complications. RESULTS: Four randomized controlled clinical trials, including 200 patients in total, with evaluable data, which satisfied our criteria, were found. There were no data on long-term outcomes. There is no reported important difference in short-term physiologic effects. Use of crystalloid was as effective as colloid in both correction of haematological values and reduction of clinical symptoms following partial exchange transfusion. CONCLUSION:
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Authors | Eugene M Dempsey, Keith Barrington |
Journal | Acta paediatrica (Oslo, Norway : 1992)
(Acta Paediatr)
Vol. 94
Issue 11
Pg. 1650-5
(Nov 2005)
ISSN: 0803-5253 [Print] Norway |
PMID | 16303705
(Publication Type: Journal Article, Meta-Analysis, Research Support, Non-U.S. Gov't, Review, Systematic Review)
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Chemical References |
- Colloids
- Crystalloid Solutions
- Isotonic Solutions
|
Topics |
- Colloids
- Crystalloid Solutions
- Exchange Transfusion, Whole Blood
(methods)
- Humans
- Infant, Newborn
- Isotonic Solutions
- Polycythemia
(therapy)
- Treatment Outcome
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