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Distribution and function of plasmids in Salmonella enterica.

Abstract
Plasmids of Salmonella enterica vary in size from 2 to more than 200 kb. The best described group of plasmids are the virulence plasmids (50-100 kb in size) present in serovars Enteritidis, Typhimurium, Dublin, Cholerae-suis, Gallinarum, Pullorum and Abortus-ovis. They all encode spvRABCD genes involved in intra-macrophage survival of Salmonella. Another group of high molecular weight plasmids are plasmids responsible for antibiotic resistance. Since most of these plasmids are conjugative, besides storage of genetic information, they contribute to the spread of genes in bacterial populations. The low molecular weight plasmids are the last group of plasmids found in S. enterica. Some of them have been shown to increase resistance to phage infection due to the presence of restriction modification systems. Despite limited knowledge on their function, their presence or absence is frequently used for strain differentiation in epidemiological studies.
AuthorsI Rychlik, D Gregorova, H Hradecka
JournalVeterinary microbiology (Vet Microbiol) Vol. 112 Issue 1 Pg. 1-10 (Jan 10 2006) ISSN: 0378-1135 [Print] Netherlands
PMID16303262 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
Chemical References
  • Virulence Factors
Topics
  • Animals
  • Drug Resistance, Bacterial (genetics)
  • Molecular Weight
  • Plasmids (genetics)
  • Salmonella Infections, Animal (microbiology)
  • Salmonella enterica (drug effects, genetics, pathogenicity)
  • Virulence (genetics)
  • Virulence Factors (genetics)

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