Abstract | BACKGROUND: Authors reviewed single center experience of intestinal transplantation for treatment of intra-abdominal neoplastic disease. METHODS: RESULTS: There were 11 graft losses; mortality with functioning graft (6), ischemic necrosis (2), acute or chronic rejection (2), and arterial thrombosis (1) during 38 months of mean follow-up. Seven patients died because of recurrent neoplasm and transplant related complications. Six patients experienced recurrent disease; three desmoid tumor (3/14), two adenocarcinoma (2/2), and one neuroendocrine tumor (1/2). Recurrent desmoid tumors were successfully treated with simple excision. Patient and graft survival in the desmoid tumor are 69.2% and 50.0% at 5 years after transplant. Among 14 survivors, 2 need parenteral nutrition or intravenous hydration. Twelve patients are working full time. CONCLUSIONS: Intestinal transplantation is a reasonable life-saving treatment for catastrophic intra-abdominal neoplastic diseases.
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Authors | Jang I Moon, Gennaro Selvaggi, Seigo Nishida, David M Levi, Tomoaki Kato, Philip Ruiz, Pablo Bejarano, Juan R Madariaga, Andreas G Tzakis |
Journal | Journal of surgical oncology
(J Surg Oncol)
Vol. 92
Issue 4
Pg. 284-91
(Dec 15 2005)
ISSN: 0022-4790 [Print] United States |
PMID | 16299803
(Publication Type: Journal Article, Research Support, N.I.H., Extramural)
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Copyright | 2005 Wiley-Liss, Inc. |
Topics |
- Abdominal Neoplasms
(surgery)
- Adolescent
- Adult
- Child, Preschool
- Duodenum
(transplantation)
- Female
- Fibromatosis, Abdominal
(pathology, surgery)
- Fibromatosis, Aggressive
(pathology, surgery)
- Graft Rejection
- Graft Survival
- Humans
- Intestines
(transplantation)
- Liver Transplantation
- Male
- Middle Aged
- Pancreas Transplantation
- Quality of Life
- Recurrence
- Stomach
(transplantation)
- Survival Analysis
- Transplantation, Homologous
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