Eosinophils, but not eosinophil peroxidase or major basic protein, are important for host protection in experimental Brugia pahangi infection.

Abstract

The attenuation of eosinophilia by the administration of monoclonal antibodies to CCR3 consistently correlates with impairment in worm elimination following primary intraperitoneal Brugia pahangi infections in mice. Host protection was unimpaired in mice deficient in eosinophil peroxidase (EPO) or major basic protein 1 (MBP-1), suggesting that eosinophils are essential in host protection but that neither EPO nor MBP-1 alone is.

• Authors: Thirumalai Ramalingam, Patricia Porte, James Lee, T V Rajan
• Journal: Infection and immunity (Infect Immun) Vol. 73 Issue 12 Pg. 8442-3 (Dec 2005) ISSN: 0019-9567 [Print] United States
• PMID: 16299347 (Publication Type: Journal Article)

Chemical References

• Antibodies, Monoclonal
• Ccr3 protein, mouse
• Receptors, CCR3
• Receptors, Chemokine
• Eosinophil Peroxidase
• Eosinophil Major Basic Protein

Topics

• Animals
• Antibodies, Monoclonal (pharmacology)
• Brugia pahangi
• Eosinophil Major Basic Protein (genetics, metabolism, physiology)
• Eosinophil Peroxidase (genetics, metabolism, physiology)
• Eosinophilia (immunology)
• Eosinophils (immunology, metabolism)
• Filariasis (immunology)
• Mice
• Mice, Mutant Strains
• Mutation
• Receptors, CCR3
• Receptors, Chemokine (drug effects, immunology)