HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Increased apolipoprotein C-III levels associated with insulin resistance contribute to dyslipidemia in normoglycemic and diabetic subjects from a triethnic population.

Abstract
Despite the major role of insulin in regulating apolipoprotein C-III (apo C-III) production, little is known about the relationship between apo C-III and insulin resistance. We examined this relationship, and the association of apo C-III with dyslipidemia, in a triethnic sample of 168 subjects with normoglycemia or type 2 diabetes. African-Americans had lower triglycerides (1.21 +/- 0.11 mmol/l) compared with Hispanics (2.01 +/- 0.14 mmol/l) and white non-Hispanics (1.83 +/- 0.15 mmol/l), regardless of gender and type 2 diabetes status (P < 0.01), but this difference was partially accounted for by ethnic difference in apo C-III levels. Metabolic syndrome was associated with high apo C-III (> 14 mg/dl) in Hispanics (OR = 5.6; 95%CI: 1.3-23.4) and white non-Hispanics (OR = 6.9; 95%CI: 1.3-36.4), but not in African-Americans. Apo C-III was the best predictor of triglycerides (R2 = 0.54, P < 0.001), after accounting for demographic and clinical variables. We found an inverse relationship between apo C-III levels and low-density lipoprotein (LDL) particle size in the type 2 diabetes subjects with (r = -0.36, P = 0.02) and without (r = -0.47, P = 0.02) the metabolic syndrome, but in normoglycemic subjects an inverse relationship was evident only in metabolic syndrome subjects (r = -0.52, P < 0.01). These results suggest that higher apo C-III may contribute to the increased cardiovascular risk in subjects with insulin resistance and type 2 diabetes through its effects on triglycerides and LDL particle size.
AuthorsHermes Florez, Armando Mendez, Paul Casanova-Romero, Carmen Larreal-Urdaneta, Sumaya Castillo-Florez, David Lee, Ronald Goldberg
JournalAtherosclerosis (Atherosclerosis) Vol. 188 Issue 1 Pg. 134-41 (Sep 2006) ISSN: 0021-9150 [Print] Ireland
PMID16298371 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
Chemical References
  • Apolipoprotein C-III
  • Lipoproteins, LDL
  • Triglycerides
Topics
  • Adult
  • Aged
  • Apolipoprotein C-III (blood)
  • Cardiovascular Diseases (etiology)
  • Diabetes Mellitus, Type 2 (ethnology, metabolism)
  • Dyslipidemias (ethnology, metabolism)
  • Ethnicity
  • Female
  • Humans
  • Hypertriglyceridemia (ethnology, metabolism)
  • Insulin Resistance
  • Lipoproteins, LDL (blood)
  • Male
  • Metabolic Syndrome (ethnology, metabolism)
  • Middle Aged
  • Particle Size
  • Risk Factors
  • Triglycerides (blood)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: