Abstract | BACKGROUND: METHODS: This was a randomized, two-arm clinical trial in an outpatient research clinic involving overweight, hyperlipidemic community volunteers motivated to lose weight. Subjects were randomized to either an LCKD (n = 59) and nutritional supplementation (including fish, borage and flaxseed oil), or a low-fat, reduced-calorie diet (LFD, n = 60). The main outcomes were fasting serum lipoprotein subclasses determined by nuclear magnetic resonance analysis. RESULTS: The mean age of subjects was 44.9 years, the mean BMI was 34.4 kg/m(2), and 76% were women. Comparing baseline to 6 months, the LCKD group had significant changes in large VLDL (-78%), medium VLDL (-60%), small VLDL (-57%), LDL particle size (+2%), large LDL (+54%), medium LDL (-42%), small LDL (-78%), HDL particle size (+5%), large HDL (+21%), and LDL particle concentration (-11%). Compared with the LFD group, the LCKD group had greater reductions in medium VLDL (p = 0.01), small VLDL (p = 0.01) and medium LDL (p = 0.02), and greater increases in VLDL particle size (p = 0.01), large LDL (p = 0.004), and HDL particle size (p = 0.05). CONCLUSIONS:
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Authors | Eric C Westman, William S Yancy Jr, Maren K Olsen, Tara Dudley, John R Guyton |
Journal | International journal of cardiology
(Int J Cardiol)
Vol. 110
Issue 2
Pg. 212-6
(Jun 16 2006)
ISSN: 0167-5273 [Print] Netherlands |
PMID | 16297472
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.)
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Chemical References |
- Cholesterol, HDL
- Dietary Carbohydrates
- Dietary Fats
- Lipoproteins
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Topics |
- Adult
- Black or African American
(statistics & numerical data)
- Ambulatory Care Facilities
- Black People
(statistics & numerical data)
- Body Mass Index
- Cholesterol, HDL
(blood)
- Diet, Fat-Restricted
- Dietary Carbohydrates
(administration & dosage)
- Dietary Fats
(administration & dosage)
- Fasting
- Female
- Humans
- Lipoproteins
(blood, classification)
- Male
- Middle Aged
- Nuclear Magnetic Resonance, Biomolecular
- Time Factors
- Weight Loss
(physiology)
- White People
(statistics & numerical data)
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