Histamine ameliorates spatial memory deficits induced by MK-801 infusion into ventral hippocampus as evaluated by radial maze task in rats.

Abstract

AIM:

To investigate the role of histamine in memory deficits induced by MK-801 infusion into the ventral hippocampus in rats.

METHODS:

An 8-arm radial maze (4 arms baited) was used to assess spatial memory.

RESULTS:

Bilateral ventral intrahippocampal (ih) infusion of MK-801 (0.3 microg/site), an N-methyl-D-aspartate (NMDA) antagonist, impaired the retrieval process in both working memory and reference memory. Intrahippocampal injection of histamine (25 or 50 ng/site) or intraperitoneal (ip) injection of histidine (25, 50 or 100 mg/kg) markedly ameliorated the spatial memory deficits induced by MK-801. Both the histamine H1 antagonist pyrilamine (0.5 or 1.0 microg/site, ih) and the H2 antagonist cimetidine (2.5 microg/site, ih) abolished the ameliorating effect of histidine (100 mg/kg, ip) on reference memory deficits, but not that on working memory deficits induced by MK-801.

CONCLUSION:

The results indicate that histamine in the ventral hippocampus can ameliorate MK-801-induced spatial memory deficits, and that histamine's effect on reference memory is mediated by postsynaptic histamine H1 and H2 receptors.

• Authors: Li-Sha Xu, Li-Xia Yang, Wei-Wei Hu, Xiao Yu, Li Ma, Lu-Ying Liu, Er-Qing Wei, Zhong Chen
• Journal: Acta pharmacologica Sinica (Acta Pharmacol Sin) Vol. 26 Issue 12 Pg. 1448-53 (Dec 2005) ISSN: 1671-4083 [Print] United States
• PMID: 16297342 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Histamine H1 Antagonists
• Histamine H2 Antagonists
• Histidine
• Dizocilpine Maleate
• Cimetidine
• Histamine
• Pyrilamine

Topics

• Animals
• Cimetidine (pharmacology)
• Dizocilpine Maleate
• Dose-Response Relationship, Drug
• Hippocampus (drug effects, physiopathology)
• Histamine (administration & dosage, pharmacology)
• Histamine H1 Antagonists (pharmacology)
• Histamine H2 Antagonists (pharmacology)
• Histidine (administration & dosage, pharmacology)
• Injections, Intraventricular
• Male
• Maze Learning (drug effects)
• Memory Disorders (chemically induced, physiopathology)
• Pyrilamine (pharmacology)
• Rats
• Rats, Sprague-Dawley