Histamine ameliorates spatial memory deficits induced by MK-801 infusion into ventral hippocampus as evaluated by radial maze task in rats.

To investigate the role of histamine in memory deficits induced by MK-801 infusion into the ventral hippocampus in rats.
An 8-arm radial maze (4 arms baited) was used to assess spatial memory.
Bilateral ventral intrahippocampal (ih) infusion of MK-801 (0.3 microg/site), an N-methyl-D-aspartate (NMDA) antagonist, impaired the retrieval process in both working memory and reference memory. Intrahippocampal injection of histamine (25 or 50 ng/site) or intraperitoneal (ip) injection of histidine (25, 50 or 100 mg/kg) markedly ameliorated the spatial memory deficits induced by MK-801. Both the histamine H1 antagonist pyrilamine (0.5 or 1.0 microg/site, ih) and the H2 antagonist cimetidine (2.5 microg/site, ih) abolished the ameliorating effect of histidine (100 mg/kg, ip) on reference memory deficits, but not that on working memory deficits induced by MK-801.
The results indicate that histamine in the ventral hippocampus can ameliorate MK-801-induced spatial memory deficits, and that histamine's effect on reference memory is mediated by postsynaptic histamine H1 and H2 receptors.
AuthorsLi-Sha Xu, Li-Xia Yang, Wei-Wei Hu, Xiao Yu, Li Ma, Lu-Ying Liu, Er-Qing Wei, Zhong Chen
JournalActa pharmacologica Sinica (Acta Pharmacol Sin) Vol. 26 Issue 12 Pg. 1448-53 (Dec 2005) ISSN: 1671-4083 [Print] China
PMID16297342 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Histamine H1 Antagonists
  • Histamine H2 Antagonists
  • Histidine
  • Dizocilpine Maleate
  • Cimetidine
  • Histamine
  • Pyrilamine
  • Animals
  • Cimetidine (pharmacology)
  • Dizocilpine Maleate
  • Dose-Response Relationship, Drug
  • Hippocampus (drug effects, physiopathology)
  • Histamine (administration & dosage, pharmacology)
  • Histamine H1 Antagonists (pharmacology)
  • Histamine H2 Antagonists (pharmacology)
  • Histidine (administration & dosage, pharmacology)
  • Injections, Intraventricular
  • Male
  • Maze Learning (drug effects)
  • Memory Disorders (chemically induced, physiopathology)
  • Pyrilamine (pharmacology)
  • Rats
  • Rats, Sprague-Dawley

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