HOMEPRODUCTSSERVICESCOMPANYCONTACTFAQResearchDictionaryPharmaMobileSign Up FREE or Login

The dental pulp: inflammatory markers and vital bleaching.

AbstractPURPOSE: To evaluate the expression of specific neuropeptides associated with inflammation, substance-P (SP) and calcitonin gene-related peptide (CGRP), after night guard vital bleaching with 10% carbamide peroxide gel. METHODS: 10 patients with four caries free premolars scheduled for orthodontic extraction had these teeth bleached with 10% Opalescence as follows: tooth #28, no treatment (control); #5, 4 days of bleaching; #12, 2 weeks of bleaching; #21, 2 weeks of bleaching, followed by 2 weeks without treatment. All teeth in the four groups were extracted at the same time. Immediately after extraction the teeth were frozen at -197 degrees C in liquid nitrogen. The pulp samples were prepared for enzyme-linked immunoabsorbent assay (ELISA) to determine the concentrations of the SP, CGRP and total protein in the pulp tissue. RESULTS: The analysis of mean SP and mean CGRP/ng protein/ml resulted in no significant differences among the four groups. It was concluded that the study did not demonstrate an increase in the release of SP and/or CGRP during night guard vital bleaching of teeth with 10% Opalescence.
AuthorsOrlando J Fugaro, Jessica O Fugaro, Bruce Matis, Richard L Gregory, Michael A Cochran, Ivar Mjör (Affiliation: San Mateo Branch Clinic, U.S. Navy, Camp Pendelton, CA, USA.)
JournalAmerican journal of dentistry (Am J Dent) Vol. 18 Issue 4 Pg. 229-32 (Aug 2005) ISSN: 0894-8275 [Print] United States
PMID16296427 (Publication Type: Journal Article)
Chemical References
  • Biological Markers
  • Drug Combinations
  • Oxidants
  • Peroxides
  • carbamide peroxide
  • Substance P
  • Urea
  • Calcitonin Gene-Related Peptide
Topics
  • Adolescent
  • Adult
  • Biological Markers
  • Calcitonin Gene-Related Peptide (analysis, biosynthesis)
  • Child
  • Dental Pulp (drug effects, metabolism)
  • Drug Combinations
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Humans
  • Male
  • Neurogenic Inflammation (chemically induced)
  • Oxidants (toxicity)
  • Peroxides (toxicity)
  • Substance P (analysis, biosynthesis)
  • Tooth Bleaching (adverse effects)
  • Urea (analogs & derivatives, toxicity)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!


Choose Username:
Email:
Password:
Verify Password:


Research Interface PRO additionally includes drill-down to evidence, articles by author, export to Excel, FDA Link and mobile subscription:
1 year subscription, $45.00 USD