A case of uterine cervical cancer presenting with granulocytosis.

Abstract

Granulocytosis occurs in 40% of patients with lung and gastrointestinal cancers, 20% of patients with breast cancer, 30% of patients with brain tumor and ovarian cancer and 10% of patients with renal cell carcinoma. Granulocytosis occurs because of production of G-CSF, GM-CSF and IL-6. Uterine cervical carcinoma with granulocytosis as a paraneoplastic syndrome, however, has been rarely reported. We recently witnessed a case of invasive squamous cell carcinoma of the uterine cervix with granulocytosis. Leukocytosis developed up to 69,000/microL, and then normalized after chemo-radiotherapy. There was no evidence of infection, tumor necrosis, glucocorticoid administration, or myeloproliferative disease by examination of a bone marrow aspirate when granulocytosis appeared. This phenomenon was probably associated with the secretion of hematopoietic growth factors such as G-CSF, GM-CSF and IL-6 by the tumor. We suggest that, like some other solid tumors, cervical cancer can present with granulocytosis as a paraneoplastic syndrome.

• Authors: Heui June Ahn, Yeon Hee Park, Yoon Hwan Chang, Sun Hoo Park, Min-Suk Kim, Baek Yeol Ryoo, Sung Hyun Yang
• Journal: The Korean journal of internal medicine (Korean J Intern Med) Vol. 20 Issue 3 Pg. 247-50 (Sep 2005) ISSN: 1226-3303 [Print] Korea (South)
• PMID: 16295785 (Publication Type: Case Reports, Journal Article)

Topics

• Female
• Granulocytes (pathology)
• Humans
• Leukocytosis (etiology)
• Middle Aged
• Paraneoplastic Syndromes (etiology)
• Uterine Cervical Neoplasms (complications, diagnosis, physiopathology)
• Uterine Neoplasms (complications, diagnosis)