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Asthma with sulfite intolerance in children: a blocking study with cyanocobalamin.

Abstract
Sulfites have been implicated as the cause of bronchospasm in some subjects with asthma. However, there is still no universally accepted explanation of the pathogenesis of these reactions. We have studied five children with asthma with metabisulfite intolerance confirmed by oral challenge testing. The challenge test with metabisulfite was repeated after premedication of all the patients with 1.5 mg of oral cyanocobalamin. In four of the five patients treated with cyanocobalamin, bronchospasm did not develop in the second metabisulfite challenge. The possible mechanisms are discussed.
AuthorsB Añíbarro, T Caballero, C García-Ara, J M Díaz-Pena, J A Ojeda
JournalThe Journal of allergy and clinical immunology (J Allergy Clin Immunol) Vol. 90 Issue 1 Pg. 103-9 (Jul 1992) ISSN: 0091-6749 [Print] United States
PMID1629495 (Publication Type: Journal Article)
Chemical References
  • Sulfites
  • metabisulfite
  • Vitamin B 12
Topics
  • Administration, Oral
  • Adolescent
  • Asthma (complications, drug therapy)
  • Bronchial Spasm (chemically induced, prevention & control)
  • Child
  • Child, Preschool
  • Dose-Response Relationship, Drug
  • Drug Evaluation
  • Drug Tolerance
  • Humans
  • Male
  • Single-Blind Method
  • Sulfites (administration & dosage, adverse effects, antagonists & inhibitors)
  • Time Factors
  • Vitamin B 12 (therapeutic use)

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