A case of adrenal gland dependent hyperadrenocorticism with mitotane therapy in a Yorkshire terrier dog.

Abstract

Hyperadrenocorticism, a disorder characterized by excessive production of cortisol by the adrenal cortex, is well-recognized in dogs. A 10-year-old, intact male, Yorkshire terrier dog was evaluated because of corneal ulceration and generalized alopecia. Diagnosis was made based on history taking, clinical signs, physical examination, and results of routine laboratory testing (complete blood count, serum biochemical analysis, and urinalysis). In addition, adrenocorticotropic hormone (ACTH) stimulation test and abdominal ultrasonography were also used to diagnose this case. The patient was diagnosed as adrenal gland neoplasia and medical therapy using the adrenocorticolytic agent, mitotane, was initiated. An ACTH stimulation test was performed after initial therapy. After successful induction was obtained, maintenance therapy with mitotane still continued.

• Authors: Young-Mi Lee, Byeong-Teck Kang, Dong-in Jung, Chul Park, Ha-Jung Kim, Ju-Won Kim, Chae-Young Lim, Eun-Hee Park, Hee-Myung Park
• Journal: Journal of veterinary science (J Vet Sci) Vol. 6 Issue 4 Pg. 363-6 (Dec 2005) ISSN: 1229-845X [Print] Korea (South)
• PMID: 16294004 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antineoplastic Agents, Hormonal
• Mitotane
• Adrenocorticotropic Hormone

Topics

• Adrenal Gland Neoplasms (complications, diagnosis, drug therapy, veterinary)
• Adrenocortical Hyperfunction (diagnosis, drug therapy, etiology, veterinary)
• Adrenocorticotropic Hormone (blood)
• Animals
• Antineoplastic Agents, Hormonal (therapeutic use)
• Dog Diseases (drug therapy)
• Dogs
• Male
• Mitotane (therapeutic use)
• Radiography, Abdominal (veterinary)
• Tomography, X-Ray (veterinary)