Abstract | BACKGROUND/PURPOSE: METHODS: RESULTS: Pulmonary arterioles from prenatal rats did not dilate in response to SNP, atrial natriuretic peptide, or 8-bromo-cGMP. Vasodilatory responses of postnatal pulmonary arterioles from control rats to SNP and 8-bromo-cGMP were significantly greater than for arterioles from rats with CDH. Zaprinast pretreatment resulted in similar responses for postnatal CDH and control arterioles to 8-bromo-cGMP. CONCLUSIONS: Postnatal pulmonary arterioles from CDH rats exhibit altered nitrovasodilator responsiveness, which may be due to rapid degradation of cGMP.
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Authors | Zoran Vukcevic, Christopher P Coppola, Chris Hults, John R Gosche |
Journal | Journal of pediatric surgery
(J Pediatr Surg)
Vol. 40
Issue 11
Pg. 1706-11
(Nov 2005)
ISSN: 1531-5037 [Electronic] United States |
PMID | 16291156
(Publication Type: Journal Article)
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Chemical References |
- Pesticides
- Phenyl Ethers
- Phosphodiesterase Inhibitors
- Purinones
- Vasodilator Agents
- Nitroprusside
- 8-bromocyclic GMP
- Nitric Oxide
- Atrial Natriuretic Factor
- zaprinast
- Cyclic GMP
- nitrofen
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Topics |
- Animals
- Arterioles
(drug effects, physiology)
- Atrial Natriuretic Factor
(pharmacology)
- Cyclic GMP
(analogs & derivatives, metabolism, pharmacology)
- Disease Models, Animal
- Hernia, Diaphragmatic
(complications, physiopathology)
- Hernias, Diaphragmatic, Congenital
- Hypertension, Pulmonary
(drug therapy, physiopathology)
- Lung
(blood supply)
- Nitric Oxide
(pharmacology)
- Nitroprusside
(pharmacology)
- Pesticides
- Phenyl Ethers
- Phosphodiesterase Inhibitors
(pharmacology)
- Purinones
(pharmacology)
- Rats
- Rats, Sprague-Dawley
- Vasodilation
(drug effects)
- Vasodilator Agents
(pharmacology)
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