4-Borono-2-[18F]fluoro-D,L-phenylalanine: a possible tracer for melanoma diagnosis with PET.

Abstract

The potential of 4-borono-2-[18F]fluoro-D,L-phenylalanine ([18F]FBPA), a flurodinated derivative of a target compound for boron neutron capture therapy, for melanoma imaging by positron emission tomography (PET) was studied using animal models. A high uptake of [18F]FBPA was found in murine B16 melanoma or in Greene's melanoma No. 179, a melanotic cell line in hamsters, for the first 6 h after injection. Whole body autoradiography using [18F]FBPA gave a clear image of the B16 tumor. The acid-insoluble 18F in the B16 increased to 27% by 6 h, and most of the free 18F was detected as [18F]FBPA in both B16 and plasma. In the hamster models, No. 179 showed a 1.7 times higher uptake than amelanotic Greene's melanoma No. 178 at 6 h post-injection, although both melanomas indicated similar metabolic activities when examined by a tracer uptake study using L-[14C]methionine, 2-deoxy-D-[14C]glucose and [3H]thymidine. [18F]FBPA may be a very promising PET tracer for melanoma imaging.

• Authors: K Ishiwata, T Ido, C Honda, M Kawamura, M Ichihashi, Y Mishima
• Journal: International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology (Int J Rad Appl Instrum B) Vol. 19 Issue 3 Pg. 311-8 (Apr 1992) ISSN: 0883-2897 [Print] England
• PMID: 1629021 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Boron Compounds
• Carbon Radioisotopes
• Fluorine Radioisotopes
• Fluorodeoxyglucose F18
• 4-borono-2-fluorophenylalanine
• Phenylalanine
• Deoxyglucose

Topics

• Animals
• Autoradiography
• Boron Compounds (metabolism, pharmacokinetics)
• Carbon Radioisotopes
• Cricetinae
• Deoxyglucose (analogs & derivatives)
• Fluorine Radioisotopes
• Fluorodeoxyglucose F18
• Melanoma, Experimental (diagnostic imaging, metabolism, pathology)
• Mesocricetus
• Mice
• Neoplasm Transplantation
• Phenylalanine (analogs & derivatives, metabolism, pharmacokinetics)
• Tissue Distribution
• Tomography, Emission-Computed (methods)
• Tumor Cells, Cultured
• Whole-Body Counting