Autosomal dominant familial chronic mucocutaneous candidiasis associated with acne rosacea.

Abstract

INTRODUCTION:

Autosomal dominant chronic mucocutaneous candidiasis (CMC) without endocrinopathy (OMIM 114580) is a well-described entity. The associations recorded with this disorder to date are intercellular adhesion molecule-1 (ICAM-1) deficiency and hyper-immunoglobulin E syndrome.

CLINICAL PICTURE:

We report a new association in a family (mother and nonidentical twin sons) where acne rosacea is a prominent feature together with CMC. In addition, antibodies to thyroid microsomal and antiparietal cell were also isolated. The autoantibodies might be associated with a current "latent" endocrinopathy in particular autoimmune thyroiditis.

TREATMENT:

The patient was treated with intermittent pulses of itraconazole for the candidiasis and doxycycline initially before being substituted with isotretinoin 6 months later for the rosacea.

OUTCOME:

The patient's candidiasis responded well and has been in remission for 3 months while his rosacea continues to improve.

• Authors: H L Ee, H H Tan, S K Ng
• Journal: Annals of the Academy of Medicine, Singapore (Ann Acad Med Singap) Vol. 34 Issue 9 Pg. 571-4 (Oct 2005) ISSN: 0304-4602 [Print] Singapore
• PMID: 16284681 (Publication Type: Case Reports, Journal Article)

Topics

• Adult
• Candidiasis, Chronic Mucocutaneous (complications, genetics)
• Humans
• Male
• Pedigree
• Rosacea (complications)