Vitamin K deficiency in children pre-bone marrow transplantation.

Abstract

This study examined the prevalence of vitamin K deficiency in children pre-bone marrow transplantation (BMT). Vitamin K status was measured by the PIVKA-II assay and prothrombin times. Blood samples were obtained before vitamin-containing TPN was infused. Results indicated that eight of 26 patients (31%) were vitamin K deficient; four cases were attributed to drug antagonism (phenytoin) and four were due to inadequate vitamin K intake, synthesis or malabsorption. Only one patient had a prolonged prothrombin time. Prothrombin time, in our study, is shown to be an ineffective screening tool to determine vitamin K status. All patients receiving phenytoin and chemotherapy are at increased risk of vitamin K deficiency.

• Authors: M A Barron, J Doyle, S Zlotkin
• Journal: Bone marrow transplantation (Bone Marrow Transplant) Vol. 37 Issue 2 Pg. 151-4 (Jan 2006) ISSN: 0268-3369 [Print] England
• PMID: 16284612 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anticonvulsants
• Vitamin K
• Phenytoin

Topics

• Adolescent
• Anticonvulsants (adverse effects, antagonists & inhibitors)
• Bone Marrow Transplantation
• Child
• Child, Preschool
• Drug Antagonism
• Female
• Humans
• Infant
• Male
• Neoplasms (complications, therapy)
• Phenytoin (administration & dosage, adverse effects)
• Prevalence
• Prothrombin Time (methods)
• Retrospective Studies
• Risk Factors
• Vitamin K (metabolism)
• Vitamin K Deficiency (blood, epidemiology, etiology)